“Chaperone” Compounds Offer New Approach to Alzheimer’s Treatment

Image of a Retromer

A team of researchers from Columbia University Medical Center (CUMC), Weill Cornell Medical College, and Brandeis University has devised a wholly new approach to the treatment of Alzheimer’s disease involving the so-called retromer protein complex.

Retromer plays a vital role in neurons, steering amyloid precursor protein (APP) away from a region of the cell where APP is cleaved, creating the potentially toxic byproduct amyloid-beta, which is thought to contribute to the development of Alzheimer’s.


Top Stories

James Shapiro Edits New Anthology on Shakespeare in Americavideo icon

James Shapiro is among the best known Shakespeare scholars in the world. His award-winning books include Shakespeare and the Jews (1995), A Year in the Life of William Shakespeare: 1599 (2005) and Contested Will: Who Wrote Shakespeare? (2010). His latest book is a departure of sorts. Shakespeare in America: An Anthology from the Revolution to Now, is a 700-page collection that Shapiro edited.


Engineering an Earthquake to Buttress the National Cathedral

National Cathedral Spire in Carleton Lab

When it came time for repairs, the Washington National Cathedral turned for help to George Deodatis, the Santiago and Robertina Calatrava Family Professor of Civil Engineering and chair of the Department of Civil Engineering and Engineering Mechanics.

Columbia on Facebook Columbia on Twitter Columbia on Google+ Columbia on iTunes U Columbia News RSS Columbia on YouTube


The Lamont-Doherty Core Repository holds one of the world’s most unique and important collections of scientific samples from the deep sea—approximately 72,000 meters of sediment cores from every major ocean and sea.
Columbia's Leadership in Climate Research

Columbia in the Headlines

The Wall Street Journal, April 21
Satellites at Night Can Shed Light on Earth's Poverty

Philadelphia Inquirer, April 21
Homes Now 'Reservoirs' for Superbug MRSA

The Huffington Post, April 20
Does Brain Scanning Research Reveal Your Real Religious Belief - More Than Church Attendance?

Bloomberg Businessweek, April 17
Umpires Favor All-Star Pitchers Even When They Don't Deserve It

Capital New York, April 15
City heat study stalls due to lack of funding